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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(05) [May 2010] >
| Title: | Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-thiones |
| Authors: | Shah, T B
Gupte, A
Patel, M R
Chaudhari, V S
Patel, H
Patel, V C |
| Keywords: | Biginelli reaction
dihydropyrimidones
N-Mannich bases
antimicrobial activity |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: |
Four series of N-Mannich bases of
3,4-dihydropyrimidine-2(1H)-thiones 7a-g, 8a-g, 9a-g and 10a-g (DHPMs) have been prepared by
Mannich reaction with seven different heterocyclic secondary amino compounds 6a-g and formaldehyde 5. In
this reaction, four different derivatives of 3,4-dihydropyrimidine-2(1H)-thiones 4a-d have been used as hydrogen active compound. These precursors
have been derived by a Biginelli reaction of four aromatic aldehydes, namely,
benzaldehyde 1a, salicylaldehyde 1b, anisaldehyde 1c and vanillin 1d, respectively with ethyl acetoacetate 2 and thiourea 3. All the four series of N-Mannich
bases have been analyzed with a view to elucidate their chemical structure by
elemental analysis and spectral studies (FTIR, 1H and 13C NMR). They are
assayed for their in vitro antimicrobial
activity against E. coli and B. subtilis bacterial species and A. niger and C. albicans fungal microorganisms. N-Mannich bases derived from
each of the four DHPMs with morpholine as a heterocyclic secondary amino
component have shown promising antimicrobacterial activity against both
bacterial and fungal microorganisms.
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| Page(s): | 578-586 |
| Source: | IJC-B Vol.49B(05) [May 2010]
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