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Title: Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-thiones
Authors: Shah, T B
Gupte, A
Patel, M R
Chaudhari, V S
Patel, H
Patel, V C
Keywords: Biginelli reaction
dihydropyrimidones
N-Mannich bases
antimicrobial activity
Issue Date: May-2010
Publisher: CSIR
Abstract:  Four series of N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-thiones 7a-g, 8a-g, 9a-g and 10a-g (DHPMs) have been prepared by Mannich reaction with seven different heterocyclic secondary amino compounds 6a-g and formaldehyde 5. In this reaction, four different derivatives of 3,4-dihydropyrimidine-2(1H)-thiones 4a-d have been used as hydrogen active compound. These precursors have been derived by a Biginelli reaction of four aromatic aldehydes, namely, benzaldehyde 1a, salicylaldehyde 1b, anisaldehyde 1c and vanillin 1d, respectively with ethyl acetoacetate 2 and thiourea 3. All the four series of N-Mannich bases have been analyzed with a view to elucidate their chemical structure by elemental analysis and spectral studies (FTIR, 1H and 13C NMR). They are assayed for their in vitro antimicrobial activity against E. coli and B. subtilis bacterial species and A. niger and C. albicans fungal microorganisms. N-Mannich bases derived from each of the four DHPMs with morpholine as a heterocyclic secondary amino component have shown promising antimicrobacterial activity against both bacterial and fungal microorganisms.
Page(s): 578-586
Source:IJC-B Vol.49B(05) [May 2010]

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