Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/8762
Title: Synthesis and <i style="">in vitro </i>study of biological activity of heterocyclic <i style="">N</i>-Mannich bases of 3,4-dihydropyrimidine-2(1<i style="">H</i>)-thiones
Authors: Shah, T B
Gupte, A
Patel, M R
Chaudhari, V S
Patel, H
Patel, V C
Keywords: Biginelli reaction
dihydropyrimidones
<i style="">N</i>-Mannich bases
antimicrobial activity
Issue Date: May-2010
Publisher: CSIR
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="country-region"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> Four series of <i style="">N</i>-Mannich bases<b style=""> </b>of 3,4-dihydropyrimidine-2(1<i style="">H</i>)-thiones <b style="">7a-g, 8a-g, 9a-g </b>and <b style="">10a-g </b>(DHPMs) have been prepared by Mannich reaction with seven different heterocyclic secondary amino compounds <b style="">6a-g</b> and formaldehyde <b style="">5</b>. In this reaction, four different derivatives of 3,4-dihydropyrimidine-2(1<i style="">H</i>)-thiones <b style="">4a-d </b>have been used as hydrogen active compound. These precursors have been derived by a Biginelli reaction of four aromatic aldehydes, namely, benzaldehyde <b style="">1a</b>, salicylaldehyde <b style="">1b</b>, anisaldehyde <b style="">1c</b> and vanillin <b style="">1d</b>,<b style=""> </b>respectively with ethyl acetoacetate <b style="">2</b> and thiourea <b style="">3</b>. All the four series of <i style="">N</i>-Mannich bases have been analyzed with a view to elucidate their chemical structure by elemental analysis and spectral studies (FTIR, <sup>1</sup>H and <sup>13</sup>C NMR). They are assayed for their <i style="">in vitro </i>antimicrobial activity against <i style="">E. coli </i>and <i style="">B. subtilis</i> bacterial species and <i style="">A. niger</i> and <i style="">C. albicans</i> fungal microorganisms. N-Mannich bases derived from each of the four DHPMs with morpholine as a heterocyclic secondary amino component have shown promising antimicrobacterial activity against both bacterial and fungal microorganisms. </smarttagtype></smarttagtype></smarttagtype>
Description: 578-586
URI: http://hdl.handle.net/123456789/8762
Appears in Collections:IJC-B Vol.49B(05) [May 2010]

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