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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(05) [May 2010] >
| Title: | ZrCl4 catalyzed efficient one-pot synthesis of novel methylene-bis-β-amino/methylene-bis-β-acetamido ketones |
| Authors: | Reddy, Ch Sanjeeva
Nagaraj, A
Srinivas, A
Reddy, G Purnachandra |
| Keywords: | Mannich-type reaction
one-pot synthesis
zirconium(IV)chloride |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | Zirconium(IV)chloride (ZrCl4) catalyzed efficient one-pot
synthesis of methylene-bis-β-amino/methylene-bis-β-acetamido ketones at room temperature
has been described. In the presence of ZrCl4, the three-component
Mannich-type reaction via a variety
of in situ generated aldimines with
various ketones, methylene-bis-methoxybenzaldehyde and aromatic amines in
ethanol, led to the formation of methylene-bis-β-amino ketones and the four-component Mannich-type reaction of
methylene-bis-methoxybenzaldehyde with ketones, acetonitrile and acetyl
chloride resulted in the corresponding methylene-bis-β-acetamido ketones in high to excellent yields. All the newly
synthesized compounds have been characterized by their spectral and elemental
analyses |
| Page(s): | 617-622 |
| Source: | IJC-B Vol.49B(05) [May 2010]
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