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|Title:||ZrCl4 catalyzed efficient one-pot synthesis of novel methylene-bis-β-amino/methylene-bis-β-acetamido ketones|
|Authors:||Reddy, Ch Sanjeeva|
Reddy, G Purnachandra
|Keywords:||Mannich-type reaction;one-pot synthesis;zirconium(IV)chloride|
|Abstract:||Zirconium(IV)chloride (ZrCl4) catalyzed efficient one-pot synthesis of methylene-bis-β-amino/methylene-bis-β-acetamido ketones at room temperature has been described. In the presence of ZrCl4, the three-component Mannich-type reaction via a variety of in situ generated aldimines with various ketones, methylene-bis-methoxybenzaldehyde and aromatic amines in ethanol, led to the formation of methylene-bis-β-amino ketones and the four-component Mannich-type reaction of methylene-bis-methoxybenzaldehyde with ketones, acetonitrile and acetyl chloride resulted in the corresponding methylene-bis-β-acetamido ketones in high to excellent yields. All the newly synthesized compounds have been characterized by their spectral and elemental analyses|
|Appears in Collections:||IJC-B Vol.49B(05) [May 2010]|
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