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IJC-B Vol.49B [2010] >
IJC-B Vol.49B(05) [May 2010] >

Title: An efficient synthesis of some substituted piperidin-4-one thiosemicarbazone derivatives as potential anticonvulsant under microwave irradiation
Authors: Rastogi, Sameer
Rastogi, Harshita
Keywords: Anticonvulsant
Issue Date: May-2010
Publisher: CSIR
Abstract: Microwave assisted organic reaction enhancement (MORE)is a  simple, clean, fast, efficient, economic and environment friendly method for the synthesis of 2, 6-diaryl-3-methyl-4-piperidones by condensation of ethyl methyl ketone, benzaldehyde, substituted aromatic aldehydes and ammonium acetate. Thiosemicarbazone derivatives of 2, 6-diaryl-3-methyl-4-piperidones have been synthesized by reaction with thiosemicarbazide. Using microwave irradiation, all the reaction could be completed in very short duration (4-7 min) with considerable increase in the yields (53.2-80.8%). All the synthesized compounds have  been evaluated for their anticonvulsant activity by maximal electroshock method. Compounds 1b, 3b and 6b have been found to exhibit excellent anticonvulsant activity.
Page(s): 547-553
Source:IJC-B Vol.49B(05) [May 2010]

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