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|Title:||An efficient synthesis of some substituted piperidin-4-one thiosemicarbazone derivatives as potential anticonvulsant under microwave irradiation|
|Abstract:||Microwave assisted organic reaction enhancement (MORE<i style="">)</i>is a simple, clean, fast, efficient, economic and environment friendly method for the synthesis of 2, 6-diaryl-3-methyl-4-piperidones by condensation of ethyl methyl ketone, benzaldehyde, substituted aromatic aldehydes and ammonium acetate. Thiosemicarbazone derivatives of 2, 6-diaryl-3-methyl-4-piperidones have been synthesized by reaction with thiosemicarbazide. Using microwave irradiation, all the reaction could be completed in very short duration (4-7 min) with considerable increase in the yields (53.2-80.8%).<b> </b>All the synthesized compounds have been evaluated for their anticonvulsant activity by maximal electroshock method. Compounds <b>1b</b>, <b>3b</b> and <b>6b</b> have been found to exhibit excellent anticonvulsant activity.|
|Appears in Collections:||IJC-B Vol.49B(05) [May 2010]|
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