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Title: A facile synthesis of carvedilol, β-adrenergic blocking agent, via a key 5-substituted-2-oxazolidinone intermediate
Authors: Madhusudhan, G
Kumar, B Anand
Chintamani, U S
Rao, M Narasimha
Udaykiran, D
Suresh, T
Kumar, V Kiran
Mukkanti, K
Keywords: Carvedilol;5-substituted-2-oxazolidinone;impurity B;β-adrenergic blocking agent;β-amino alcohol
Issue Date: May-2010
Publisher: CSIR
Abstract: A facile synthesis of Carvedilol via a key 5-substituted-2-oxazolidinone intermediate is described and this approach avoids the formation of bis side product (impurity B). This approach could be useful for the preparation of many β-amino alcohols without formation of bis impurity.
Page(s): 606-610
Appears in Collections:IJC-B Vol.49B(05) [May 2010]

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