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|Title:||Studies on phosphine free Pd-salen complexes as effective catalysts for aqueous Suzuki reaction|
|Authors:||Borhade, Sanjay R|
Waghmode, Suresh B
aryl boronic acid
|Abstract:||<smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> Palladium complexes of the salen ligands, <i style="">N</i>,<i style="">N</i>'-bis(salicylidene)-ethylenediamine and <i style="">N</i>,<i style="">N</i>'-bis(salicylidene)-1,2-phenylenediamine have been explored for their catalytic activity in a<b style=""> </b>phosphine-free aqueous Suzuki reaction. The various reaction parameters have been systematically optimized with respect to various solvents, bases, temperatures and Pd concentrations. The studies conclude that 1:1 DMF to water solvent ratio, Na<sub>2</sub>CO<sub>3 </sub>as base and 0.5 mol% of palladium at 90°C is apt for Suzuki reactions. Rapid transformation of substituted aryl iodides and aryl bromides into corresponding biaryls has been observed with excellent yield ranging from 70-86%, under optimized conditions. </smarttagtype>|
|Appears in Collections:||IJC-B Vol.49B(05) [May 2010]|
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