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Title: Studies on phosphine free Pd-salen complexes as effective catalysts for aqueous Suzuki reaction
Authors: Borhade, Sanjay R
Waghmode, Suresh B
Keywords: Suzuki reaction;biaryls;Pd-salen;phosphine-free;aryl boronic acid
Issue Date: May-2010
Publisher: CSIR
Abstract:  Palladium complexes of the salen ligands, N,N'-bis(salicylidene)-ethylenediamine and N,N'-bis(salicylidene)-1,2-phenylenediamine have been explored for their catalytic activity in a phosphine-free aqueous Suzuki reaction. The various reaction parameters have been systematically optimized with respect to various solvents, bases, temperatures and Pd concentrations. The studies conclude that 1:1 DMF to water solvent ratio, Na2CO3 as base and 0.5 mol% of palladium at 90°C is apt for Suzuki reactions. Rapid transformation of substituted aryl iodides and aryl bromides into corresponding biaryls has been observed with excellent yield ranging from 70-86%, under optimized conditions.
Page(s): 565-572
Appears in Collections:IJC-B Vol.49B(05) [May 2010]

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