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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.12 [2005] >
IJCT Vol.12(2) [March 2005] >
| Title: | Determination of heavy metals in selected drug substances by inductively coupled plasma – mass spectrometry |
| Authors: | Murty, A S R Krishna
Kulshresta, U C
Rao, T Nageswara
Talluri, M V N Kumar |
| Keywords: | Inductivity coupled plasma
heavy metal determination
dicyclomineHCl
ethambutol
pyrazinamide
furazolidone |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | G01J 3/00; C22B 4/04 |
| Abstract: | Heavy metal contents in dicyclomineHCl,
ethambutol, pyrazinamide and furazolidone drugs were determined by inductively
coupled plasma (ICP) - mass spectrometry (MS). The drugs were analyzed for Ti,
Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Hg, Pb metals by selecting a suitable isotope.
Cr, Fe, Ti and Cu were observed to be highest in dicyclomineHCl, ethambutol,
pyrazinamide and furazolidone respectively. Ni and Hg were absent in all the
four drugs, while traces of Cd were present in ethambutol and pyrazinamide.
Analytical results showed that ICP-MS method is useful for monitoring inorganic
impurities present in such drugs. |
| Page(s): | 229-231 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.12(2) [March 2005]
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