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IJCT Vol.12(2) [March 2005] >


Title: Determination of heavy metals in selected drug substances by inductively coupled plasma – mass spectrometry
Authors: Murty, A S R Krishna
Kulshresta, U C
Rao, T Nageswara
Talluri, M V N Kumar
Keywords: Inductivity coupled plasma
heavy metal determination
dicyclomineHCl
ethambutol
pyrazinamide
furazolidone
Issue Date: Mar-2005
Publisher: CSIR
IPC CodeG01J 3/00; C22B 4/04
Abstract: Heavy metal contents in dicyclomineHCl, ethambutol, pyrazinamide and furazolidone drugs were determined by inductively coupled plasma (ICP) - mass spectrometry (MS). The drugs were analyzed for Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Hg, Pb metals by selecting a suitable isotope. Cr, Fe, Ti and Cu were observed to be highest in dicyclomineHCl, ethambutol, pyrazinamide and furazolidone respectively. Ni and Hg were absent in all the four drugs, while traces of Cd were present in ethambutol and pyrazinamide. Analytical results showed that ICP-MS method is useful for monitoring inorganic impurities present in such drugs.
Page(s): 229-231
ISSN: 0975-0991 (Online); 0971-457X (Print)
Source:IJCT Vol.12(2) [March 2005]

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