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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.12 [2005] >
IJCT Vol.12(1) [January 2005] >
| Title: | Sensitive titrimetric and spectrophotometric assay methods for chlorpromazine with bromate-bromide mixture and two dyes |
| Authors: | Basavaiah, K
Nagegowda, P
Prameela, H C
Somashekar, B C |
| Keywords: | Chlorpromazine determination
titrimetry
spectrophotometry
bromate-bromide
dyes |
| Issue Date: | Jan-2005 |
| Publisher: | CSIR |
| IPC Code: | C07D 279/00; G01J 3/00; A61K |
| Abstract: | Three new methods using titrimetry and
spectrophotometry are described for the determination of chlorpromazine
hydrochloride with bromate-bromide mixture as the oxidimetric-brominating agent
and two dyes, methyl orange and indigo carmine. In titrimetry (method A), the
drug is treated with a measured excess of bromate-bromide reagent in acid
medium, and the residual bromine is determined iodometrically. The two spectrophotometric
methods involve the addition of a measured excess of bromate-bromide mixture to
drug solution in acidic conditions followed by estimation of the unreacted
bromine by treating with a fixed amount of methyl orange (method B) or indigo
carmine (method C) and measuring the absorbance at 520 nm (method B) or 610 nm
(method C). Titrimetric procedure is applicable over 1-10 mg range and the
reaction stoichiometry is found to be 1:1 (drug: bromate). In
spectrophotometric methods, the systems obey Beer’s law over 1.0-6.0  g mL-1
and 2.5-15.0 g mL-1, for methods B and C, respectively. The molar
absorptivity and Sandell sensitivity values and the limits of detection and
quantification are reported for both spectrophotometric methods. The proposed
methods were applied to the determination of chlorpromazine hydrochloride in
tablets and injections with the assay results in the range of 98.63 to 101.88%
of label claim. The reliability of the methods was assessed by parallel
determination by the official method and by recovery studies. |
| Page(s): | 25-29 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.12(1) [January 2005]
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