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IJTK Vol.04(3) [July 2005] >


Title: Antidiarrhoeal activity of antidiarrhoeal Unani formulation in rats
Authors: Khan, M Aleem
Khan, Naeem A
Qasmi, Iqbal A
Ahmad, Ghufran
Zafar, Shadab
Keywords: Antidiarrhoeal Activity
Diarrhoea
Medicinal Plants
Issue Date: Jul-2005
Publisher: CSIR
IPC Code Int. Cl.7: A61K 35/78, A61P1/12
Abstract: Aqueous extract of antidiarrhoeal formulation (ADF) containing Holarrhena antidysenterica Wall, Aegle marmelos Correa ex Koen and Punica granatum Linn. was investigated for antidiarrhoeal activity against charcoal induced gut motility and serotonin induced diarrhoea in experimental rats. The control, standard and test groups of experimental animals were administered with distilled water, Lomotil and ADF (150 mg and 300 mg/kg) orally. Charcoal and serotonin were administered after 30 min in each group of first and second experiment. The distance traveled by charcoal in small intestine was measured after 30 and 60 min of charcoal administration and diarrhoea was observed every 30 min for six hours after serotonin administration. ADF causing significant reduction in the distance traveled by charcoal and serotonin induced diarrhoea. Thus ADF may have the potential to reduce the diarrhoea in rats.
Page(s): 271-274
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Source:IJTK Vol.04(3) [July 2005]

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