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Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.04 [2005] >
IJTK Vol.04(3) [July 2005] >
| Title: | Antidiarrhoeal activity of antidiarrhoeal Unani formulation in rats |
| Authors: | Khan, M Aleem
Khan, Naeem A
Qasmi, Iqbal A
Ahmad, Ghufran
Zafar, Shadab |
| Keywords: | Antidiarrhoeal Activity
Diarrhoea
Medicinal Plants |
| Issue Date: | Jul-2005 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.7: A61K 35/78, A61P1/12 |
| Abstract: | Aqueous extract of antidiarrhoeal
formulation (ADF) containing Holarrhena
antidysenterica Wall, Aegle marmelos
Correa ex Koen and Punica granatum
Linn. was investigated for antidiarrhoeal activity against charcoal induced gut
motility and serotonin induced diarrhoea in experimental rats. The control,
standard and test groups of experimental animals were administered with distilled
water, Lomotil and ADF (150 mg and 300 mg/kg) orally. Charcoal and serotonin
were administered after 30 min in each group of first and second experiment.
The distance traveled by charcoal in small intestine was measured after 30 and
60 min of charcoal administration and diarrhoea was observed every 30 min for
six hours after serotonin administration. ADF causing significant reduction in
the distance traveled by charcoal and serotonin induced diarrhoea. Thus ADF may
have the potential to reduce the diarrhoea in rats. |
| Page(s): | 271-274 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.04(3) [July 2005]
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