|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(05) [May 2010] >
| Title: | Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity |
| Authors: | Karanth, Jyothsna
Jeevaratnam, K |
| Keywords: | Carnitine supplementation
Dietary fat
Liver
Membrane phospholipids composition
Mitochondrial enzymes
Physical activity
Skeletal muscle |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | Effect of carnitine supplementation in
enhancing fat utilization was investigated by looking into its effects on
mitochondrial respiratory enzymes activity in liver and muscle as well as on membrane fatty acid
profile in rats fed with hydrogenated fat (HF) and MUFA-rich peanut oil (PO) with or without exercise. Male Wistar rats were fed HF-diet
(4 groups, 8 rats in each group) or PO-diet (4 groups, 8 rats in each group),
with or without carnitine for 24 weeks. One group for each diet acted as
sedentary control while the other groups were allowed swimming for 1 hr a day,
6 days/week, for 24 weeks. The PO diet as well as exercise increased the
activities of mitochondrial enzymes, NADH
dehydrogenase, NADH oxidase, cytochrome C reductase, cytochrome oxidase,
while carnitine supplementation further augmented the oxidative capacity of
both liver and muscle significantly by enhancing the activity of carnitine
palmitoyl transferase and the respiratory chain enzymes. These effects can be
attributed to the enhanced unsaturated fatty acids in phospholipids of
mitochondria and may be due to increased fluidity of the membrane in these
rats. Results of this study show a significant health promoting effects of
carnitine supplementation which could be further augmented by regular exercise. |
| Page(s): | 503-510 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(05) [May 2010]
|
|
