NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(05) [May 2010] >


Title: Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-α and skeletal muscle glycogen in type 2 diabetic rats
Authors: Kirana, H
Srinivasan, B P
Keywords: Cyclea peltata
Glycogen
Insulin
TNF-α
Type 2 diabetes
Issue Date: May-2010
Publisher: CSIR
Abstract: In view of multi-dimensional activity of plant drugs beneficial to complex disorders like diabetes, the present study has been undertaken to evaluate the effect of aqueous extract of C. peltata roots on serum glucose, lipid profile, insulin, inflammatory marker namely tumour necrosis factor (TNF)-α and muscle glycogen in type 2 diabetic rats. Aqueous extract of C. peltata at 40 and 60 mg/kg dose significantly decreased both the fasting and postprandial blood glucose of type 2 diabetic rats; 60 mg/kg dose having more pronounced effect on hyperglycemia. An enhanced insulin levels by the aqueous extract is primary for its glucose and lipid lowering activity. The extract significantly decreased the elevated TNF-α in type 2 diabetic rats. The extract at 40 and 60 mg/kg dose increased the glycogen levels in skeletal muscle by 58 and 60% respectively. Improved glycogen in peripheral tissue such as skeletal muscle indicates the ability of plant drug to combat insulin resistance of type 2 diabetes.
Page(s): 499-502
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(05) [May 2010]

Files in This Item:

File Description SizeFormat
IJEB 48(5) 499-502.pdf155.19 kBAdobe PDFView/Open
 Current Page Visits: 906 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 588015 since 06-Feb-2009  Last updated on 18-Sep-2014Webmaster: nopr@niscair.res.in