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Title: Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats
Authors: Mahesh, Radhakrishnan
Pandey, Dilip Kumar
Katiyar, Shruti
Kukade, Gaurav
Viyogi, Shruti
Rudra, Anjuman
Keywords: Anti-depressants;Anxiety;Depression;Traumatic brain injury
Issue Date: May-2010
Publisher: CSIR
Abstract: Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed   to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes’ anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic -like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury.
Page(s): 466-473
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(05) [May 2010]

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