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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(05) [May 2010] >
| Title: | Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats |
| Authors: | Mahesh, Radhakrishnan
Pandey, Dilip Kumar
Katiyar, Shruti
Kukade, Gaurav
Viyogi, Shruti
Rudra, Anjuman |
| Keywords: | Anti-depressants
Anxiety
Depression
Traumatic brain injury |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | Disruption of normal neuronal networks and
neurotransmitters like serotonin and norepinephrine levels in post traumatic
brain injury (TBI) are observed to be
the primary causative agent for depression/anxiety. This communication reports
the efficacy of various classes’ anti-depressants in the treatment of
depression/anxiety following TBI in rats. Chronic treatment with
anti-depressants (escitalopram and venlafaxine) leads to improvement in the
depressive/anxiogenic -like behaviour in the TBI rat and corroborates the
notion of the involvement of serotonin and norepinephrine in the behavioural
consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine
significantly reversed the effect of TBI as compared to vehicle-treated TBI
group. The results showed a quantitative battery of neuro-behavioural
functional assessments that correlates with neuronal damage following traumatic
brain injury. |
| Page(s): | 466-473 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(05) [May 2010]
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