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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(05) [May 2010] >
| Title: | Effect of dihydrotestosterone on gastrointestinal tract of male Alzheimer’s disease transgenic mice |
| Authors: | Karri, Sritulasi
Martinez, Veronica Acosta
Coimbatore, Gopalakrishnan |
| Keywords: | Alzheimer’s disease
Amyloid precursor protein
Colon microflora
Dihydrotestosterone
GI tract
Morphometrics |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | The cause of
Alzheimer’s disease (AD) is still unknown. While research contributions
identifying brain as locus of the disease is growing, evidence of severely
impaired gastrointestinal (GI) functions with ageing too is accumulating, there
is an equal dearth of information on GI tract in AD condition. The aim of this
study was to assess the molecular, histological, morphological and microflora
alterations of GI tract in male Alzheimer’s transgenic mice. The present study also investigates the
effect of dihydrotestosterone (DHT) treatment (1 mg/kg) on AD mice.
Histoarchitecture data revealed a significant decrease in the villi number,
muscular layer thickness, villi length, width, crypt length, enterocyte length
and nuclei length. A shift in colon feces microbial community composition was
observed by fatty acid methyl ester analysis. Amyloid precursor protein (APP)
expression levels in intestine significantly increased in AD mice revealing its
toxicity. DHT treatment attenuated the effect caused by AD on GI morphometrics,
APP expression and colon micro flora population. These results for the first
time reveal the quantitative and qualitative characteristics of GI tract in
male Alzheimer’s disease transgenic mice. |
| Page(s): | 453-465 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(05) [May 2010]
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