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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(05) [May 2010] >
| Title: | Anti-allergic, anti-inflammatory and anti-lipidperoxidant effects of Cassia occidentalis Linn. |
| Authors: | Sreejith, G
Latha, P G
Shine, V J
Anuja, G I
Suja, S R
Sini, S
Shyamal, S
Pradeep, S
Shikha, P
Rajasekharan, S |
| Keywords: | Anti-allergy
Anti-inflammatory
Anti-lipid peroxidation
Cassia occidentalis
Mast cell degranulation
Malondialdehyde |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: |
Cassia occidentalis Linn.
mast cell degranulation at a dose of 250 mg/kg, showed dose dependent
stabilizing activity towards human RBC, with is widely used in traditional
medicine of India
to treat a number of clinical conditions including allergy and inflammatory
manifestations. In the present study anti-allergic, anti-inflammatory and anti-oxidant
properties of C. occidentalis whole
plant ethanolic extract (CO) was
investigated. Effects of CO on rat mast cell
degranulation inhibition and human red blood cell (HRBC) membrane stabilization
were studied in vitro following
standard methods. The anti lipidperoxidant effects of CO were also studied in vitro. Effect of CO on
carrageenan-induced mouse paw oedema inhibition was also assessed. CO
significantly decreased maximum protection of 80.8% at 15 μg/ml. The extract
also caused significant reduction in malondialdehyde (MDA) levels of murine
hepatic microsomes at 100 μg/ml (56%) and significantly reduced carrageenan
induced inflammation in mice at a dose of 250 mg/kg. Results of the present
study indicated that CO inhibited mast cell degranulation, stabilized HRBC
membrane thereby alleviating immediate hypersensitivity besides showing anti
oxidant activity.
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| Page(s): | 494-498 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(05) [May 2010]
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