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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(05) [May 2010] >
| Title: | Effect of Convolvulus pluricaulis Choisy. and Asparagus racemosus Willd on learning and memory in young and old mice: A comparative evaluation |
| Authors: | Sharma, Komal
Bhatnagar, Maheep
Kulkarni, S K |
| Keywords: | Asparagus racemosus
Convolvulus pluricaulis
Elevated plus maze
Learning
Memory |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | A dose
dependent enhancement of memory was observed with A. racemosus and C.
pluricaulis treatment as compared to control group when tested on second
day. A. racemosus and C. pluricaulis at the dose of 200 mg/kg,
po showed significantly higher percent retentions, than piracetam. Multiple
treatment with A. racemosus and C. pluricaulis for three days also
demonstrated significant dose dependent increase in percent retentions as
compared to control group. The effect was more prominent with C. pluricaulis as compared with
piracetam and A. racemosus. A
significantly lower percent retention in aged mice was observed as compared to
young mice. Aged mice (18-20 months) showed higher transfer latency (TL) values
on first and second day (after 24 h) as compared to young mice, indicating
impairment in learning and memory. Pretreatment with A. racemosus and C.
pluricaulis for 7 days enhanced memory in aged mice, as significant
increase in percent retention was observed. Significantly higher retention was
observed with C. pluricaulis (200
mg/kg; po) as compared with piracetam (10 mg/kg/; po). Post-trial
administration of C.pluricaulis and A.
racemosus extract demonstrated significant decrease in latency time during
retention trials. Hippocampal regions associated with the learning and memory
functions showed dose dependent increase in AChE activity in CA 1 with A. reacemosus and CA3 area with C. pluracaulis treatment. The underlying
mechanism of these actions of A. racemosus and
C. pluricaulis may be attributed to their
antioxidant, neuroprotective and cholinergic properties. |
| Page(s): | 479-485 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(05) [May 2010]
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