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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(2) [April 2010] >
| Title: | Hypolipidemic and antioxidant activity of Anthocephalus indicus (Kadam) root extract |
| Authors: | Kumar, Vishnu
Mahdi, Farzana
Chander, Ramesh
Singh, Ranjana
Mahdi, Abbas Ali
Khanna, Ashok Kumar
Bhatt, Sanjay
Kushwaha, Rajeev Singh
Jawad, Kalbe
Saxena, Jitendra Kumar
Singh, Raj Kumar |
| Keywords: | Cholic acid
Deoxycholic acid
Lipid peroxides
Superoxide dismutase
Catalase
Lipoprotein lipase
Triglyceride lipase
Lecithin cholesterol acyltransferase |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | The present
study was carried out to explore the anti-diabetic, anti-dyslipoproteinemic and
anti-oxidant activities of Anthocephalus indicus root extract in
alloxan-induced (150 mg/kg body wt.) diabetic rats. A marked increase in plasma
levels of glucose and lipid peroxides accompanied with an elevation in the
lipids and apoprotein levels of serum very low density lipoprotein (VLDL) and
low density lipoprotein (LDL) following decrease in lipid and protein
constituents of high density lipoprotein (HDL) were observed. The alterations
in lipoprotein pattern was associated with inhibition of lipolytic and
antioxidant enzymes. Oral administration of root extract (500 mg/kg body wt.)
for 30 days in dyslipidemic animals resulted in significant decrease in plasma
glucose, total cholesterol, phospholipids, triglyceride and lipid peroxides.
The decrease of lipids and apoprotein levels of VLDL and LDL were followed by
stimulation of plasma post-heparin lipolytic activity and lecithin cholesterol acyltransferase
as well as hepatic superoxide dismutase and catalase activities. Lipid and
apoprotein levels of HDL were also recovered partially on treatment with root
extract. |
| Page(s): | 104-109 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(2) [April 2010]
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