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Title: Hypolipidemic and antioxidant activity of Anthocephalus indicus (Kadam) root extract
Authors: Kumar, Vishnu
Mahdi, Farzana
Chander, Ramesh
Singh, Ranjana
Mahdi, Abbas Ali
Khanna, Ashok Kumar
Bhatt, Sanjay
Kushwaha, Rajeev Singh
Jawad, Kalbe
Saxena, Jitendra Kumar
Singh, Raj Kumar
Keywords: Cholic acid
Deoxycholic acid
Lipid peroxides
Superoxide dismutase
Lipoprotein lipase
Triglyceride lipase
Lecithin cholesterol acyltransferase
Issue Date: Apr-2010
Publisher: CSIR
Abstract: The present study was carried out to explore the anti-diabetic, anti-dyslipoproteinemic and anti-oxidant activities of Anthocephalus indicus root extract in alloxan-induced (150 mg/kg body wt.) diabetic rats. A marked increase in plasma levels of glucose and lipid peroxides accompanied with an elevation in the lipids and apoprotein levels of serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL) following decrease in lipid and protein constituents of high density lipoprotein (HDL) were observed. The alterations in lipoprotein pattern was associated with inhibition of lipolytic and antioxidant enzymes. Oral administration of root extract (500 mg/kg body wt.) for 30 days in dyslipidemic animals resulted in significant decrease in plasma glucose, total cholesterol, phospholipids, triglyceride and lipid peroxides. The decrease of lipids and apoprotein levels of VLDL and LDL were followed by stimulation of plasma post-heparin lipolytic activity and lecithin cholesterol acyltransferase as well as hepatic superoxide dismutase and catalase activities. Lipid and apoprotein levels of HDL were also recovered partially on treatment with root extract.
Page(s): 104-109
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.47(2) [April 2010]

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