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Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(2) [April 2010] >
| Title: | Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats |
| Authors: | Verma, Nitin
Khosa, R L |
| Keywords: | Zanthoxylum armatum
Hepatoprotective activity |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | Zanthoxylum
armatum DC (Rutaceae) is extensively used in
indigenous system of medicine as a tonic, carminative, stomachic and
anthelmintic. In the present study, the hepatoprotective
activity of the leaves ethanolic extract of Z. armatum (EEZA) was evaluated in CCl4-induced
hepatotoxicity in rats. The extract at a dose of 500 mg/kg registered a significant decrease in
the levels of serum glutamyl
oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT),
alkaline phosphatase (ALKP), and serum bilurubin (SBLN) and liver inflammation, which was supported by histopathological
studies on liver,
thus exhibited a significant hepatoprotective activity. The phytochemical
screening of defatted ethanolic extract showed the presence of sterols,
alkaloids, flavonoids, and reducing sugars. |
| Page(s): | 124-127 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(2) [April 2010]
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