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IJBB Vol.47(2) [April 2010] >


Title: Indicators of oxidative stress in thyroid cancer
Authors: Koduru, Bhargav
Tejaswini
Thakur, Ajit
Kamath, Shobha U
Shenoy, Kallya Rajgopal
Kamath, Ullas
Reshma, K
Keywords: Thyroid cancer
Carbonyl
Thiols
Myeloperoxidase
FRAP
Free radical
Oxidative damage
Issue Date: Apr-2010
Publisher: CSIR
Abstract: Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, pre- and post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.
Page(s): 121-123
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.47(2) [April 2010]

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