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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(2) [April 2010] >
| Title: | Indicators of oxidative stress in thyroid cancer |
| Authors: | Koduru, Bhargav
Tejaswini
Thakur, Ajit
Kamath, Shobha U
Shenoy, Kallya Rajgopal
Kamath, Ullas
Reshma, K |
| Keywords: | Thyroid cancer
Carbonyl
Thiols
Myeloperoxidase
FRAP
Free radical
Oxidative damage |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity
and the levels of protein thiols and carbonyls were estimated in the blood
samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as
well as in healthy controls
(n = 10) to study the extent of damage caused by tumor tissue
proliferation-induced oxidative stress and to ascertain that oxidative stress
levels drop, when there was no proliferation. A significant decrease
(p<0.001) in the levels of serum protein thiols and FRAP as well as a
significant increase (p<0.001) in the levels of protein carbonyls and MPO
activity in the blood of thyroid cancer patients before surgery was observed as
compared to healthy controls. All the parameters studied also showed a
significant difference (p<0.001) in their respective levels in thyroid
cancer patients, pre- and post-thyroidectomy. These findings present the role
of oxidative stress as a pathological implication of thyroid cancer. |
| Page(s): | 121-123 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(2) [April 2010]
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