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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)]
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NPR Vol.4(6) [November-December 2005] >

Title: Effect of lamellarin alkaloid mixture obtained from marine Ascidian Didemnum obscurum and its synergistic action with Beauveria bassiana on Culex quinquefasciatus (Say) larvae
Authors: Rao, M Srinivasa
Misra, Sunil
Murty, U Suryanarayana
Venkateswarlu, Y
Srinivasulu, M
Keywords: Culex quinquefasciatus
Didemnum obscurum
Lamellarin alkaloids mixture
Beauveria bassiana
Issue Date: Dec-2005
Publisher: CSIR
IPC CodeInt. cl.7 A61K 35/00, A01N 25/00
Abstract: A preliminary laboratory trial was undertaken to determine the bioefficacy of lamellarin alkaloid mixture (LMA), obtained from the Indian Ascidian, Didemnum obscurum against II and III stage of Culex quinquefasciatus (CQ) larvae. For this study, Esfenvalrate (EFV) a synthetic pyrithroid was taken as positive control. Both these compounds at different concentrations caused mortality of II and III instar of CQ larvae between 48 to 96 hours. When compared the toxicity efficacy of these compounds, EFV was shown to be more toxic than the LMA. From the synergistic study, II and III instar larvae were exposed to LC50 of Beauveria bassiana (Bb) along with the lowest concentration of LMA (1ppm) and EFV (0.05ppm), which showed a significant increase in the morality rate within 48 hours. Between these two compounds tested, EFV is a known neurotoxic agent and hence not advisable to apply on mosquito control. As LMA is reported for its many biologically important properties, it also showed larvicidal activity against CQ larvae. From this study, it is concluded that synergistic action of B. bassiana along with LMA can be utilized for mosquito control operations. The detailed results are discussed in this paper.  
Page(s): 460-465
ISSN: 0975-1092 (Online); 0972-592X (Print)
Source:NPR Vol.4(6) [November-December 2005]

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