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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
NPR Vol.4 [2005] >
NPR Vol.4(5) [September-October 2005] >
| Title: | Food |
| Issue Date: | Oct-2005 |
| Publisher: | CSIR |
| Abstract: | Glucagon-like
peptide-1 (7-36) amide (GLP-1) is the most potent physiological insulinotropic
hormone in humans. It is a potent blood glucose-lowering hormone that stimulates
the secretion of insulin from pancreatic beta-cells. Scientists of Japan
produced large amounts of a GLP-1 analogue, [Ser8, Gln26,
Asp34]-GLP-1, which is resistant to trypsin-digestion, as part of a
chimeric rice seed storage protein, a 26kDa globulin, in genetically modified
rice seeds. Junction sites between GLP-1 analogue and globulin were replaced by
tryptic cleavage sites. The highest level of GLP-1 analogue accumulation was
≈20–50μg per seed. We found that GLP-1 analogue derived from trypsin-digested
genetically modified rice seeds stimulated insulin secretion from a mouse
pancreatic beta-cell line, MIN6. These findings suggest that the consumption of
genetically modified rice seeds containing elevated levels of the GLP-1 analogue
may control blood glucose levels in humans. |
| Page(s): | 420-422 |
| ISSN: | 0975-1092 (Online); 0972-592X (Print) |
| Source: | NPR Vol.4(5) [September-October 2005]
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