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Title: A simple two-step synthesis of avenanthramides, constituents of oats (Avena sativa L)
Authors: Kamat, Shrivallabh P
Parab, Sulaksha J
Keywords: Oats;Avena sativa;Antioxidants;Avenanthramides;Anthranilic acid;Meldrum’s acid;2-[(carboxyacetyl)amino]benzoic acid
Issue Date: Dec-2007
Publisher: CSIR
Abstract: A simple two-step general procedure has been developed to prepare naturally occurring and synthetic avenanthramides, constituents of oats (Avena sativa L). Reaction of anthranilic acid 1 with Meldrum’s acid 2 gives half amide of malonic acid 3 which on condensation with different benzaldehyde derivatives 4a-m gives avenanthramides 5a-m of which 5a-d are natural, 5e-g are their methyl ethers and 5h-m are synthetic.
Page(s): 2074-2078
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(12) December 2007]

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