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Title: Antiulcerogenic effect of some plants extracts
Authors: Atta, A H
Nasr, Soad M
Mouneir, Samar M
Keywords: Antiulcers;Medicinal plants;Mentha microphylla;Conyza dioscoridis;Conyza linifolia;Zygophyllum album;Bidens bipinnata;Cynanchum acutum;Plantago major;Schouwia thebaica
Issue Date: Aug-2005
Publisher: CSIR
IPC Code: Int. cl.7A61K 35/78, A61P 1/04
Abstract: Methanol extracts were prepared from aerial parts of 8 medicinal plants and evaluated for their potential antiulcerogenic effects using ethanol and Aspirin - induced gastric ulcerations in rats. Oral administration of the methanol extract (400 mg/kg-) of Bidens bipinnata Linn., Zygophyllum album Linn. f.Plantago major Linn. (leaves) and Schouwia thebaica Webb. significantly (P< 0.01) decreased the average ulcer index with a curative ratio ranged from 100% for B. bipinnata to 58.3% for S. thebaica in the ethanol-induced gastric ulceration. Mentha microphylla C. Koch., Conyza linifolia Willd., C. dioscoridis (Linn.) Desf., Cynanchum acutum Linn. and P. major (seeds) decreased the ulcer index, however, their curative ratios were below 50% but higher than the reference drug Ranitidine (curative ratio 38.9%). B. bipinnata, Z. album and P. major (leaves) in a dose of 400 mg/kg significantly decreased the number of gastric ulcer and decreased total protein in gastric juice in aspirin-induced gastric ulceration. The total acidity was significantly (P< 0.01) decreased by all tested plant extracts. Based on the decreased ulcer index, increased curative ratio, decreased number of gastric ulcers and decreased total protein and total acidity, B. bipinnata, Z. album and P. major leaves in a dose of 400 mg/kg produced a potent antiulcerogenic effect against alcohol- and aspirin-induced gastric ulcer. Moderate effect was produced by S. thebaica.
Page(s): 258-263
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.4(4) [July-August 2005]

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