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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
NPR Vol.4 [2005] >
NPR Vol.4(4) [July-August 2005] >
| Title: | Antiulcerogenic effect of some plants extracts |
| Authors: | Atta, A H
Nasr, Soad M
Mouneir, Samar M |
| Keywords: | Antiulcers
Medicinal plants
Mentha microphylla
Conyza dioscoridis
Conyza linifolia
Zygophyllum album
Bidens bipinnata
Cynanchum acutum
Plantago major
Schouwia thebaica |
| Issue Date: | Aug-2005 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.7― A61K 35/78, A61P 1/04 |
| Abstract: | Methanol extracts were
prepared from aerial parts of 8 medicinal plants and evaluated for their
potential antiulcerogenic effects using ethanol and Aspirin - induced gastric
ulcerations in rats. Oral administration of the methanol extract (400
mg/kg-) of Bidens bipinnata Linn., Zygophyllum album Linn. f., Plantago major Linn. (leaves)
and Schouwia thebaica Webb.
significantly (P< 0.01) decreased the average ulcer index with a curative
ratio ranged
from 100% for B. bipinnata to 58.3%
for S. thebaica in the
ethanol-induced gastric ulceration. Mentha microphylla C. Koch., Conyza
linifolia Willd., C. dioscoridis
(Linn.) Desf., Cynanchum acutum Linn.
and
P. major (seeds) decreased the ulcer
index, however, their curative ratios were below 50% but higher than the
reference drug Ranitidine (curative ratio 38.9%). B. bipinnata, Z. album and P. major
(leaves)
in a dose of 400 mg/kg significantly
decreased the number of gastric ulcer and decreased total protein in gastric
juice in aspirin-induced gastric ulceration. The total acidity was significantly
(P< 0.01) decreased by all tested plant extracts. Based on the decreased ulcer
index, increased curative ratio, decreased number of gastric ulcers and
decreased
total protein and total acidity, B.
bipinnata, Z. album and P. major
leaves in a dose of 400
mg/kg produced
a potent antiulcerogenic effect against alcohol- and aspirin-induced gastric
ulcer. Moderate effect was produced by S. thebaica. |
| Page(s): | 258-263 |
| ISSN: | 0975-1092 (Online); 0972-592X (Print) |
| Source: | NPR Vol.4(4) [July-August 2005]
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