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http://nopr.niscair.res.in/handle/123456789/807Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jadhav, Dhanaji H | - |
| dc.contributor.author | Ramaa, C S | - |
| dc.date.accessioned | 2008-04-07T10:56:36Z | - |
| dc.date.available | 2008-04-07T10:56:36Z | - |
| dc.date.issued | 2007-12 | - |
| dc.identifier.issn | 0376-4699 | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/807 | - |
| dc.description | 2064-2067 | en_US |
| dc.description.abstract | A series of twelve 2',4'-difluorinated chalcones have been synthesized by Claisen-Schmidt condensation of 2',4'-difluoroacetophenone with appropriately substituted benzaldehydes. These compounds have then been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat paw oedema model. Compounds 1, 7, 10 and 11 have activity comparable to indomethacin at 20 mg kg⁻¹ by oral route. | en_US |
| dc.language.iso | en_US | en_US |
| dc.source | IJCB Vol.46B(12) [December 2007] | en_US |
| dc.subject | Chalcones | en_US |
| dc.subject | 2',4'-difluoroacetophenone | en_US |
| dc.subject | Substituted benzaldehydes | en_US |
| dc.subject | Claisen-Schmidt condensation | en_US |
| dc.subject | Anti-inflammatory activity | en_US |
| dc.title | Synthesis and anti-inflammatory activity of fluorinated chalcone derivatives | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJC-B Vol.46B(12) December 2007] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 46B(12) (2007) 2064-2067.pdf | 122.5 kB | Adobe PDF | View/Open |
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