Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/807
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dc.contributor.authorJadhav, Dhanaji H-
dc.contributor.authorRamaa, C S-
dc.date.accessioned2008-04-07T10:56:36Z-
dc.date.available2008-04-07T10:56:36Z-
dc.date.issued2007-12-
dc.identifier.issn0376-4699-
dc.identifier.urihttp://hdl.handle.net/123456789/807-
dc.description2064-2067en_US
dc.description.abstractA series of twelve 2',4'-difluorinated chalcones have been synthesized by Claisen-Schmidt condensation of 2',4'-difluoroacetophenone with appropriately substituted benzaldehydes. These compounds have then been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat paw oedema model. Compounds 1, 7, 10 and 11 have activity comparable to indomethacin at 20 mg kg⁻¹ by oral route.en_US
dc.language.isoen_USen_US
dc.sourceIJCB Vol.46B(12) [December 2007]en_US
dc.subjectChalconesen_US
dc.subject2',4'-difluoroacetophenoneen_US
dc.subjectSubstituted benzaldehydesen_US
dc.subjectClaisen-Schmidt condensationen_US
dc.subjectAnti-inflammatory activityen_US
dc.titleSynthesis and anti-inflammatory activity of fluorinated chalcone derivativesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.46B(12) December 2007]

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