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IJC-B Vol.46B(12) December 2007] >


Title: Synthesis and anti-inflammatory activity of fluorinated chalcone derivatives
Authors: Jadhav, Dhanaji H
Ramaa, C S
Keywords: Chalcones
2',4'-difluoroacetophenone
Substituted benzaldehydes
Claisen-Schmidt condensation
Anti-inflammatory activity
Issue Date: Dec-2007
Abstract: A series of twelve 2',4'-difluorinated chalcones have been synthesized by Claisen-Schmidt condensation of 2',4'-difluoroacetophenone with appropriately substituted benzaldehydes. These compounds have then been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat paw oedema model. Compounds 1, 7, 10 and 11 have activity comparable to indomethacin at 20 mg kg⁻¹ by oral route.
Page(s): 2064-2067
ISSN: 0376-4699
Source:IJC-B Vol.46B(12) December 2007]

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