NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)]
NPR Vol.4 [2005] >
NPR Vol.4(2) [March-April 2005] >

Title: Effect of Garlic and Red Clover extracts on adenosine deaminase enzyme activities in cancerous and non-cancerous human liver tissues
Authors: Durak, İlker
Avcı, Aslıhan
Göçmen, Erdal
Devrim, Erdinç
Keywords: Liver Cancer
Adenosine deaminase
Allium sativum
Red clover
Trifolium pretense
Issue Date: Apr-2005
Publisher: CSIR
IPC CodeInt. cl.7A61P 43/00, A61P 35/00, A61K 35/78
Abstract: Possible effects of aqueous garlic (Allium sativum Linn.) and red clover (Trifolium pratense Linn.) extracts on adenosine deaminase (ADA) activities were investigated in cancerous and non-cancerous human liver tissues and results were compared with those of Fludarabine, a known ADA inhibitor. Ten cancerous and 10 non-cancerous adjacent liver tissues were obtained from patients with metastatic type liver cancer by surgical operations. Kinetic analyses were carried out to establish Vmax and Km values of the reaction catalyzed by ADA in the presence or absence of inhibitor. ADA activity was found to be lower in the cancerous tissues compared with non-cancerous tissues. Aqueous garlic and red clover extracts induced significant inhibition ADA activity in both the tissues. Inhibition percentage was relatively higher in the cancerous tissues as compared with non-cancerous tissues. Furthermore, we observed that inhibition percentage induced by garlic and red clover extracts were higher than those of Fludarabine at the concentrations studied.
Page(s): 97-101
ISSN: 0975-1092 (Online); 0972-592X (Print)
Source:NPR Vol.4(2) [March-April 2005]

Files in This Item:

File Description SizeFormat
NPR 4(2) 97-101.pdf181.04 kBAdobe PDFView/Open
 Current Page Visits: 74 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 163935 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: