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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
NPR Vol.4 [2005] >
NPR Vol.4(2) [March-April 2005] >
| Title: | Effect of Garlic and Red Clover extracts on adenosine deaminase enzyme activities in cancerous and non-cancerous human liver tissues |
| Authors: | Durak, İlker
Avcı, Aslıhan
Göçmen, Erdal
Devrim, Erdinç |
| Keywords: | Liver Cancer
Adenosine deaminase
ADA
Garlic
Allium sativum
Red clover
Trifolium pretense |
| Issue Date: | Apr-2005 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.7— A61P 43/00, A61P 35/00, A61K 35/78 |
| Abstract: | Possible effects of aqueous garlic (Allium
sativum Linn.) and red clover (Trifolium pratense Linn.)
extracts on adenosine deaminase (ADA) activities were investigated in cancerous
and non-cancerous human liver tissues and results were compared with those of
Fludarabine, a known ADA inhibitor. Ten cancerous and 10 non-cancerous adjacent
liver tissues were obtained from patients with metastatic type liver cancer by
surgical operations. Kinetic analyses were carried out to establish Vmax and Km
values of the reaction catalyzed by ADA in the presence or absence of inhibitor.
ADA activity was found to be lower in the cancerous tissues compared with
non-cancerous tissues. Aqueous garlic and red clover extracts induced
significant inhibition ADA activity in both the tissues. Inhibition percentage
was relatively higher in the cancerous tissues as compared with non-cancerous
tissues. Furthermore, we observed that inhibition percentage induced by garlic
and red clover extracts were higher than those of Fludarabine at the
concentrations studied. |
| Page(s): | 97-101 |
| ISSN: | 0975-1092 (Online); 0972-592X (Print) |
| Source: | NPR Vol.4(2) [March-April 2005]
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