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NPR Vol.5(1) [January-February 2006] >


Title: Development of quality control methods for polyherbal formulation, Chyawanprash
Authors: Kasar, Rahul P
Laddha, K S
Chaudhary, Jayesh
Shukla, Anil
Keywords: Chyawanprash
Phytoconstituents
Physicochemical Parameter
Standardization
Stability study
Issue Date: Feb-2006
Publisher: CSIR
IPC CodeInt. cl.7A61K 35/78
Abstract: Chyawanprash is a traditional polyherbal formulation which is widely, used as tonic, rejuvenator, anabolic, immunomodulator and memory enhancer. Chyawanprash contains the pulp of Emblica officinalis Gaertn. as the prime ingredient, along with powder and extract of several other herbs. It is observed that the consistency and taste varies from one manufacturer to another. Even these variations are observed in the same pharmaceutical company in different manufacturing batches. Hence, it is the need of the hour to standardize the raw materials to obtain product consistency. With the advent of new analytical tools and sophisticated instrumental technology, the quality assurance profile for a crude drug or its bioactive constituents can be made possible. Two in-house batch of Chyawanprash was prepared according to the procedure described in text Charaksamhita and remaining one Chyawanprash sample was procured from market. These batches were evaluated by physicochemical methods and its bio-efficacy was determined by various biological methods like antioxidant study, microbial contamination study and finally stability study was performed on the formulation according to the ICH guidelines.  The results of two in-house batches were found in close proximation with the marketed batch. The method used for determination of quality control of Chyanwanprash was found to be precise and reproducible and can be used for quality control of other marketed formulations. These studies on Chyawanprash were noticed reproducible and precise and may be considered as the methods for its quality control.
Page(s): 33-41
ISSN: 0975-1092 (Online); 0972-592X (Print)
Source:NPR Vol.5(1) [January-February 2006]

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