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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
NPR Vol.5 [2006] >
NPR Vol.5(2) [March-April 2006] >
| Title: | Protective effect of Syzygium cuminii (Linn.) Skeels seed extract on lipid peroxidation in alloxan induced diabetic rats |
| Authors: | Krishnamoorthy, P
Vaithinathan, S
Bhuvaneswari, A |
| Keywords: | Black plum
Jamun
Syzygium cuminii
Syzygium jambolanum
Seed extract
Antioxidant
Alloxan
Diabetes
Lipid peroxidation
Oxidative stress |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.7 —A61K 35/78, A61P 3/10, A61P 39/06 |
| Abstract: | The effect of
Black plum, Syzygium cuminii (Linn.)
Skeels (syn. S. jambolanum DC.) seed extract on lipid peroxidation in alloxan
induced diabetic rats was studied. Alloxan 150mg (mg/kg body weight) increased
significantly the glucose level in blood and induced the Lipid Peroxidation
(LPO) in liver. The antioxidant enzymes Catalase (CAT), Reduced Glutathione
(GSH), Glutathione peroxidase (GPx), Superoxide dismutase (SOD) in liver were
decreased. Oral administration of the extract for 15 days to alloxan treated
animals showed remarkable increase in the level of antioxidant enzymes and
reduced the level of lipid peroxidation activity and blood glucose. The results
suggest that seed extract of the plant is an antioxidant and acute
hyperglycaemic drug and might be used in the regulation of lipid peroxidation
without detectable adverse side effects. |
| Page(s): | 103-107 |
| ISSN: | 0975-1092 (Online); 0972-592X (Print) |
| Source: | NPR Vol.5(2) [March-April 2006]
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