Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/7937
Title: Facile synthesis of acyclic analogues of carbocyclic nucleoside as potential anti-HIV pro-drug
Authors: Siddiqui, Ibadur R
Singh, Pravin K
Srivastava, Vishal
Singh, J
Keywords: Michael addition
montmorillonite K 10
control aldol condensation
chemoselective reduction
microwave irradiation
Issue Date: Apr-2010
Publisher: CSIR
Abstract: Microwave induced montmorillonite K 10 clay catalyzed Michael addition of sulphur nucleophile, (4-oxo-butyl)-dithio­carbamic acid 1 to 4-arylidene-5(4H)-oxazolones 2a-j followed by ring transformation of the resultant Michael adducts 3a-j in solvent-free conditions gives 4a-j in excellent yield. Coexistence of acidic and basic sites on surface of montmoril­lonite K 10 accelerates the organic reactions synergistically. The control Aldol condensation of compound 4a-j with HCHO gives compound 5a-j, which upon chemoselective reduction with NaBH4 gives the title compound 6a-j.  This process minimizes the mechanical loss of the intermediate during the process of isolation, and thus increases the yield and decreases the cost and time.
Description: 512-520
URI: http://hdl.handle.net/123456789/7937
Appears in Collections:IJC-B Vol.49B(04) [April 2010]

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