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Title: Synthesis and study of chlorosubstituted 4-aroyl and 4-alkoyl-pyrazolines, pyrazoles and their effect on some flowering plants
Authors: Mahale, Jaishree D
Manoja, S C
Belsare, N G
Rajput, P R
Keywords: Valeric acid
Issue Date: Apr-2010
Publisher: CSIR
Abstract: Some new chlorosubstituted 4-aroyl/alkoylpyrazolines <b>5a,b</b> and 4-aroyl/alkoylpyrazoles <b style="">7a,b</b> have been synthesized by condensation of 1-(2′-hydroxy-3′-5′-dichlorophenyl)-3-aryl/alkyl-1-3-propanedione <b style="">3a,b</b> and valeraldehyde by Baker-Venkatraman transformation of corresponding aroyl/alkoyloxyacetophenones. Aroyl/Alkoyloxyacetophenones <b style="">2a,b</b> undergo intramolecular Claisen condensation to form 1-(2′-hydroxy-3′-5′-dichloro­phenyl)-3-aryl/alkyl-1,3-propanediones <b style="">3a,b</b> which on treatment with aliphatic aldehyde in ethanol containing little piperidine forms 3-aroyl/alkoylchromanones <b>4a,b</b>. From these 3-aroyl/alkoylchromanones <b style="">4a,b </b>4-aroyl/alkoylpyrazolines <b style="">5a,b</b> are synthesized. 3-Aroyl/Alkoylchromanones <b style="">4a,b</b> are converted into 3-aroyl/alkoylchromones <b style="">6a,b</b>. The 3-aroyl/alkoylchromones <b style="">6a,b</b> on treatment with Ph.NHNH<sub>2</sub>.HCl in dioxane containing small amount of piperidine furnish 4-aroyl/alkoylpyrazoles <b>7a,b</b>.<b> </b>The structures of the newly synthesized chlorosubstituted 4-aroyl /alkoylpyrazolines <b>5a,b</b> and 4-aroyl/alkoylpyrazoles <b>7a,b</b> have been elucidated on the basis of spectral analysis and their homogeneity has been established by TLC.
Description: 505-511
Appears in Collections:IJC-B Vol.49B(04) [April 2010]

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