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Title: A novel one pot room temperature ionic liquid mediated synthesis of 1,5-benzodiazepine ribofuranosides
Authors: Yadav, Ashok K
Kumar, Manoj
Yadav, Tripti
Jain, Renuka
Keywords: Benzodiazepines;ribofuranosides;ionic liquid;o-phenylenediamine;ketones
Issue Date: Apr-2010
Publisher: CSIR
Abstract: A novel one pot ecofriendly synthesis of 7-substituted/7,8-disubstituted-2,2,4-trisubstituted-1-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2,3-dihydro-1,5-benzodiazepines have been accomplished stepwise, i.e. reacting o-phenylenediamine and a ketone in the first step followed by addition of β-D-ribofuranose-1-bromo-2,3,5-tribenzoate. The ionic liquids employed are 1,3-di-n-butylimidazolium bromide [BBIM]Br, 1-butyl-3-methylimidazolium bromide [BMIM]Br, 1-butyl-3-methylimidazolium tetrafluoroborate, [BMIM]BF4, 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM]PF6, and 1-methoxyethyl-3-methylimidazolium mesylate [MOEMIM]Ms. The yields (72-90%) of the targeted compounds are excellent.
Page(s): 461-468
Appears in Collections:IJC-B Vol.49B(04) [April 2010]

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