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NPR Vol.6(5) [September-October 2007] >


Title: Evaluation of the antipyretic potential of methanol extract of the leaves of Abies spectabilis (D. Don) Spach.
Authors: Visnoi, Satya Prakash
Basu, Anindya
Alam, S k Mahasin
Samanta, Soma
Jha, Tarun
Keywords: Abies spectabilis
Antipyretic
Methanol extract
Yeast-induced pyrexia
Issue Date: Oct-2007
Publisher: CSIR
IPC CodeInt. cl.8A61K 36/00, A61K 36/15, A61K 127/00, A61P 29/00
Abstract: Methanol extract of leaves of Abies spectabilis (D. Don) Spach. (MEAS) was evaluated for the antipyretic potential on normal body temperature and yeast induced pyrexia in rats. MEAS showed significant activity at intraperitonial (i.p.) doses of 200 and 400mg/kg body weight. The extract, when administered at a dose of 200mg/kg body weight caused significant lowering of body temperature up to 3h. With 400 mg/kg body weight dose it caused significant lowering of body temperature up to 6h after administration. In the model of yeast induced elevation of body temperature MEAS showed dose-dependant lowering of the body temperature up to 4h at both the doses. The results obtained, were comparable to that of paracetamol, a standard antipyretic agent.
Page(s): 369-371
ISSN: 0975-1092 (Online); 0972-592X (Print)
Source:NPR Vol.6(5) [September-October 2007]

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