Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/7885
Title: <b style="">Evaluation of the antipyretic potential of methanol extract of the leaves of </b> <b style=""><i style="">Abies</i></b><b style=""><i style=""> spectabilis </i>(D. Don) Spach.</b><b style=""></b>
Authors: Visnoi, Satya Prakash
Basu, Anindya
Alam, S k Mahasin
Samanta, Soma
Jha, Tarun
Keywords: <i style="">Abies</i><b style=""><i style=""> </i></b><i style="">spectabilis</i>
Antipyretic
Methanol extract
Yeast-induced pyrexia
Issue Date: Oct-2007
Publisher: CSIR
Series/Report no.: <b>Int. cl.<sup>8</sup>— </b>A61K 36/00, A61K 36/15, A61K 127/00, A61P 29/00 <b> </b>
Abstract: Methanol extract of leaves of <b style=""><i style="">Abies</i></b><b style=""><i style=""> spectabilis </i>(D. Don) Spach.</b><b style=""> </b>(MEAS) was evaluated for the antipyretic potential on normal body temperature and yeast induced pyrexia in rats. MEAS showed significant activity at intraperitonial (i.p.) doses of 200 and 400mg/kg body weight. The extract, when administered at a dose of 200mg/kg body weight caused significant lowering of body temperature up to 3h. With 400 mg/kg body weight dose it caused significant lowering of body temperature up to 6h after administration. In the model of yeast induced elevation of body temperature MEAS showed dose-dependant lowering of the body temperature up to 4h at both the doses. The results obtained, were comparable to that of paracetamol, a standard antipyretic agent.
Description: 369-371
URI: http://hdl.handle.net/123456789/7885
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.6(5) [September-October 2007]

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