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Title: Inhibition of CCl4 – induced liver fibrosis by Trigonella foenum-graecum Linn.
Authors: Thaakur, Santh Rani
Saraswathy, GR
Maheswari, E
Kumar, N Sunil
Hazarathiah, T
Sowmya, K
Reddy, P Dwarakanadha
Kumar, B Ramesh
Keywords: Liver fibrosis;CCl4;Antifibrotic effect;Hepatoprotective;Fenugreek;Trigonella foenum-graecum Linn
Issue Date: Feb-2007
Publisher: CSIR
IPC Code: Int. cl.8A61K 36/00, A61K 36/48, A61P 1/16
Abstract: Trigonella foenum-graecum Linn. (Fenugreek) belonging to the family Fabaceae, is a well known plant in Unani and Ayurvedic medicine. In the present study an attempt was made to explore the antifibrotic effect of ethanolic extract of this plant. Liver fibrosis was induced in rats by CCl4 (carbon tetrachloride) orally 1 ml/kg for 28 days. The extent of liver fibrosis was assessed by measuring the level of liver hydroxyproline (HP), serum enzymes and total bilirubin (TBL) levels due to deposition of collagen. The liver weight of the animals was increased following CCl4 administration. The administration of ethanolic extract reduced the liver weight of CCl4 treated animals and treatment with ethanolic extract of the plant reduced significantly the HP, serum enzyme and TBL level and inhibited liver fibrosis induced by CCl4.
Page(s): 11-17
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.6(1) [January-February 2007]

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