01-Feb-2015
06:05:37 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(12) December 2007] >
| Title: | Enzymatic syntheses of L-valyl, L-leucyl and L-isoleucyl esters of carbohydrates using Candida rugosa lipase |
| Authors: | Somashekar, Bhandya R
Divakar, Soundar |
| Keywords: | Candida rugosa lipase
Diastereomeric
Esters
Enzymatic
Esterification
Amino acids
Carbohydrates
L-valyl
L-leucyl
L-isoleucyl |
| Issue Date: | Dec-2007 |
| Publisher: | CSIR |
| Abstract: | L-Valyl 1 L-leucyl 2 and L-isoleucyl 3 esters of carbohydrates 4-14 have been prepared through lipase catalysis using Candida rugosa lipase in organic media. This enzymatic esterification involving unprotected and unactivated L-amino acids 1-3 and carbohydrates, comprising, aldohexoses 4-6, ketohexose 7, pentoses 8-9, disaccharides 10-12 and carbohydrate alcohols 13-14, results in the formation of both monoesters (1-O-, 2-O-, 3-O-, 4-O, 5-O-, 6-O- and 6'-O-) and diesters (1,6-di-O-, 2,5-di-O-, 2,6-di-O-, 3,6-di-O-, 4,6-di-O- and 6,6’-di-O-) with conversion yields in the range 21-68%. Among 70 esters synthesized on the whole, 65 esters are reported here for the first time. |
| Page(s): | 2026-2044 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(12) December 2007]
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