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Title: | Enzymatic syntheses of L-valyl, L-leucyl and L-isoleucyl esters of carbohydrates using Candida rugosa lipase |
Authors: | Somashekar, Bhandya R Divakar, Soundar |
Keywords: | Candida rugosa lipase;Diastereomeric;Esters;Enzymatic;Esterification;Amino acids;Carbohydrates;L-valyl;L-leucyl;L-isoleucyl |
Issue Date: | Dec-2007 |
Publisher: | CSIR |
Abstract: | L-Valyl 1 L-leucyl 2 and L-isoleucyl 3 esters of carbohydrates 4-14 have been prepared through lipase catalysis using Candida rugosa lipase in organic media. This enzymatic esterification involving unprotected and unactivated L-amino acids 1-3 and carbohydrates, comprising, aldohexoses 4-6, ketohexose 7, pentoses 8-9, disaccharides 10-12 and carbohydrate alcohols 13-14, results in the formation of both monoesters (1-O-, 2-O-, 3-O-, 4-O, 5-O-, 6-O- and 6'-O-) and diesters (1,6-di-O-, 2,5-di-O-, 2,6-di-O-, 3,6-di-O-, 4,6-di-O- and 6,6’-di-O-) with conversion yields in the range 21-68%. Among 70 esters synthesized on the whole, 65 esters are reported here for the first time. |
Page(s): | 2026-2044 |
URI: | http://hdl.handle.net/123456789/781 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.46B(12) December 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 46B(12) (2007) 2026-2044.pdf | 290.04 kB | Adobe PDF | View/Open |
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