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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(12) December 2007] >
| Title: | Synthesis, spectral studies and biological activity of novel 3H-1,5-benzodiazepine derivatives |
| Authors: | Kumar, Rajesh
Joshi, Y C |
| Keywords: | Pyrazolo[4,3-d]pyrimidin-7-one
β-diketones/ β-ketoesters
Silica chloride
o-phenylenediamine
3H-1,5-benzodiazepines
Antimicrobial
Anthelmintic |
| Issue Date: | Dec-2007 |
| Publisher: | CSIR |
| Abstract: | Chlorination of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo [4, 3-d] pyrimidin-7-one 1 with POCl₃ affords 5-(2-ethoxyphenyl)-1-methyl-7-chloro-1H-pyrazolo [4, 3-d] pyrimidine 2. Further compound 2 is condensed with different β-diketones / β-ketoesters3a-e, to obtain new β-diketones/ β-ketoesters 4a-e. The synthesized new β-diketones/ β-ketoesters (4a-e) and o-phenylenediamine (o-PDA) gives biologically active 3H-1,5-benzodiazepines 5a-e. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds 5a-e have been screened for antimicrobial, antifungal and anthelmintic activity. |
| Page(s): | 2021-2025 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(12) December 2007]
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