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IJC-B Vol.46B(12) December 2007] >


Title: Synthesis, spectral studies and biological activity of novel 3H-1,5-benzodiazepine derivatives
Authors: Kumar, Rajesh
Joshi, Y C
Keywords: Pyrazolo[4,3-d]pyrimidin-7-one
β-diketones/ β-ketoesters
Silica chloride
o-phenylenediamine
3H-1,5-benzodiazepines
Antimicrobial
Anthelmintic
Issue Date: Dec-2007
Publisher: CSIR
Abstract: Chlorination of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo [4, 3-d] pyrimidin-7-one 1 with POCl₃ affords 5-(2-ethoxyphenyl)-1-methyl-7-chloro-1H-pyrazolo [4, 3-d] pyrimidine 2. Further compound 2 is condensed with different β-diketones / β-ketoesters3a-e, to obtain new β-diketones/ β-ketoesters 4a-e. The synthesized new β-diketones/ β-ketoesters (4a-e) and o-phenylenediamine (o-PDA) gives biologically active 3H-1,5-benzodiazepines 5a-e. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds 5a-e have been screened for antimicrobial, antifungal and anthelmintic activity.
Page(s): 2021-2025
ISSN: 0376-4699
Source:IJC-B Vol.46B(12) December 2007]

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