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Indian Journal of Chemistry -Section B (IJC-B) >
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IJC-B Vol.46B(12) December 2007] >

Title: Proline ureas: Synthesis and pharmacological evaluation as VLA-4 antagonists
Authors: Sattigeri, Viswajanani J
Soni, Ajay
Dastidar, Sunanda G
Ray, Abhijit
Ahmad, Sharif
Gupta, Jung B
Salman, Mohammad
Keywords: VLA-4 antagonists
Proline urea
Issue Date: Dec-2007
Publisher: CSIR
Abstract: VLA-4 has been identified as a relatively new target for the development of “non-steroidal” alternatives for the treatment of asthma and related respiratory inflammatory diseases. In continuation of search to identify potent VLA-4 antagonists, a series of novel proline urea derivatives have been synthesized. The newly synthesized compounds are evaluated as potential VLA-4 antagonists in vitro and are found to exhibit moderate VLA-4 inhibitory activity.
Page(s): 2004-2020
ISSN: 0376-4699
Source:IJC-B Vol.46B(12) December 2007]

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