|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.69 [2010] >
JSIR Vol.69(04) [April 2010] >
| Title: | Study of inclusion complexes of valsartan with  -cyclodextrin and hydroxypropyl -cyclodextrin |
| Authors: | Nalawade, Pravin
Kadam, Vilasrao
Hirlekar, Rajashree |
| Keywords: | Co-evaporation method
Drug dissolution
Inclusion complexes |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | This study presents improvement in solubility and
dissolution rate of valsartan (VAL) using -cyclodextrin (CD) and hydroxypropyl--cyclodextrin (HP-CD). Formation and characterization of solid inclusion
complexes were investigated by DSC, FTIR, SEM, 1HNMR and in-vitro dissolution studies.
Preparation method influenced physical properties of binary mixtures. Inclusion
complexes obtained by co-evaporation method showed higher in vitro drug dissolution rates. |
| Page(s): | 295-299 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.69(04) [April 2010]
|
|
