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JSIR Vol.69(04) [April 2010] >

Title: Study of inclusion complexes of valsartan with -cyclodextrin and hydroxypropyl -cyclodextrin
Authors: Nalawade, Pravin
Kadam, Vilasrao
Hirlekar, Rajashree
Keywords: Co-evaporation method
Drug dissolution
Inclusion complexes
Issue Date: Apr-2010
Publisher: CSIR
Abstract: This study presents improvement in solubility and dissolution rate of valsartan (VAL) using -cyclodextrin (CD) and hydroxypropyl--cyclodextrin (HP-CD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, 1HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-evaporation method showed higher in vitro drug dissolution rates.
Page(s): 295-299
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.69(04) [April 2010]

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