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|Title:||Study of inclusion complexes of valsartan with -cyclodextrin and hydroxypropyl -cyclodextrin|
|Keywords:||Co-evaporation method;Drug dissolution;Inclusion complexes|
|Abstract:||This study presents improvement in solubility and dissolution rate of valsartan (VAL) using -cyclodextrin (CD) and hydroxypropyl--cyclodextrin (HP-CD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, 1HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-evaporation method showed higher in vitro drug dissolution rates.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.69(04) [April 2010]|
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