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Title: Study of inclusion complexes of valsartan with <img src='/image/spc_char/beta.gif' border=0>-cyclodextrin and hydroxypropyl <img src='/image/spc_char/beta.gif' border=0>-cyclodextrin
Authors: Nalawade, Pravin
Kadam, Vilasrao
Hirlekar, Rajashree
Keywords: Co-evaporation method
Drug dissolution
Inclusion complexes
Issue Date: Apr-2010
Publisher: CSIR
Abstract: This study presents improvement in solubility and dissolution rate of valsartan (VAL) using <img src='/image/spc_char/beta.gif' border=0>-cyclodextrin (<img src='/image/spc_char/beta.gif' border=0>CD) and hydroxypropyl-<img src='/image/spc_char/beta.gif' border=0>-cyclodextrin (HP-<img src='/image/spc_char/beta.gif' border=0>CD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, <sup>1</sup>HNMR and <i>in-vitro </i>dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-evaporation method showed higher <i>in vitro </i>drug dissolution rates.
Description: 295-299
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.69(04) [April 2010]

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