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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(1) [March 2010] >
| Title: | Anti-inflammatory, analgesic and anti-lipid peroxidation studies on leaves of Commiphora caudata (Wight & Arn.) Engl. |
| Authors: | Annu, W
Latha, P G
Shaji, J
Anuja, G I
Suja, S R
Sini, S
Shyamal, S
Shine, V J
Shikha, P
Rajasekharan, S |
| Keywords: | Anti-inflammatory
Analgesic
Antioxidant
Commiphora caudata
Lipid peroxidation |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.8— A61K 36/00, A61K 36/328, A61K 127/00, A61P 29/00, A61P 39/06 |
| Abstract: | The present study investigates the
anti-inflammatory and analgesic properties of ethanol extract of leaves of Commiphora caudata (Wight & Arn.) Engl. The anti-inflammatory activity was
evaluated by carrageenan induced paw oedema in Wistar albino rats and analgesic
effect by acetic acid induced writhing assay in Swiss albino mice. Our findings
showed that the oral administration of the extract significantly inhibited
carrageenan induced paw oedema and acetic acid induced writhing effects and
were comparable to standard drugs, Indomethacin and Aspirin, respectively. The
extract also showed significant inhibition of FeCl2-ascorbic acid
stimulated lipid peroxidation in rat liver homogenate in vitro. It can therefore, be concluded from the present study
that the ethanolic extract of C. caudata
possesses potent anti-inflammatory and analgesic properties. |
| Page(s): | 44-48 |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.1(1) [March 2010]
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