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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(04) [April 2010] >
| Title: | Effects of long-term ethanol consumption on adhesion molecules in liver |
| Authors: | Das, Subir Kumar
Mukherjee, Sukhes
Vasudevan, D M |
| Keywords: | Adhesion molecule
Cytokines
Ethanol
Liver |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: |
Adhesion molecules play an
important role in the pathogenesis of several diseases. In this study,
expression of adhesion molecules was examined in the setting of chronic alcohol
induced liver damage of male albino Wistar strain rats (16-18 weeks-old, 200-220
g) in a time dependent manner. Decreased protein level and increased activities
of liver marker enzymes in response to the chronic ethanol (1.6 g ethanol/kg body
weight/day) exposure, indicated that these animals suffered from liver damage
in a time-dependent manner. Flow
cytometric analysis revealed that chronic ethanol treatment induced intercellular
adhesion molecule-1, vascular
cell adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression in liver tissues of rats with
duration of ethanol exposure. The results suggest that the adhesion
molecules may be associated with the initiation of hepatic injury during
alcohol intoxication.
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| Page(s): | 394-401 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(04) [April 2010]
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