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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(04) [April 2010] >
| Title: | Neuroprotective effect of hydroalcoholic extract of dried fruits of Trapa bispinosa Roxb on lipofuscinogenesis and fluorescence product in brain of D-galactose induced ageing accelerated mice |
| Authors: | Ambikar, D B
Harle, U N
Khandare, R A
Bore, V V
Vyawahare, N S |
| Keywords: | Fluorescence product
Lipid peroxidation
Lipofuscin granules
Trapa bispinosa |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | Effect of hydroalcoholic
extract T. bispinosa (TB) was studied
on fluorescence product and biochemical parameter like lipid peroxidation,
catalase activity and glutathione peroxidase activity in the brain of female
albino mice. Ageing was accelerated by the treatment of 0.5 ml 5% D-galactose
for 15 days. This resulted in increased fluorescence product, increase lipid peroxidation
and decrease antioxidant enzyme like glutathione peroxides and catalase in
cerebral cortex. After co-treatment with hydroalcoholic extract of TB (500
mg/kg, po) there was decrease in fluorescence product in cerebral cortex.
Moreover, TB inhibited increase lipid peroxidation and restores glutathione
peroxidase and catalase activity in cerebral cortex as compare to ageing
accelerated control group. To conclude TB found to be effective antioxidative
agent which could to some extent reverse D-galactose induced ageing changes
resulted due to oxidative damage. |
| Page(s): | 378-382 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(04) [April 2010]
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