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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(04) [April 2010] >
| Title: | Effect of antioxidant vitamins A, C, E and their analogues on azo-dye binding protein in liver of rats treated with p-dimethylaminoazobenzene |
| Authors: | Velanganni, A Antony Joseph
Balasundaram, C |
| Keywords: | Antioxidant vitamins A, C and E
Azo-dye binding protein
p-Dimethylaminoazobenzene |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | p-Dimethylaminoazobenzene
(DAB) is an azo-dye and known to cause liver tumour in rats. Azo-dye binding
protein is a specific cytosolic protein involved in the translocation of azo-dye
carcinogen metabolites from liver cytoplasm into the nucleus. Administration of
vitamin A (40,000 and 50,000 IU), L-ascorbic acid (500 and 1,000 mg) and
vitamin E succinate (200–500 mg) reduced the amount of azo-dye binding protein
in liver of rats treated with DAB. Supplementation of high doses of vitamin A
acetate, vitamin A palmitate, sodium ascorbate, ascorbyl palmitate and vitamin
E acetate had no effect on the quantity of azo-dye binding protein in liver.
When the vitamin mixture was given, the level of azo-dye binding protein
decreased in the liver at all the studied doses, which may be due to their
synergistic effect. |
| Page(s): | 373-377 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(04) [April 2010]
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