|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(04) [April 2010] >
| Title: | Differential effects of nitric oxide synthase inhibitors on anxiety in unstressed and stressed mice |
| Authors: | Gilhotra, Neeraj
Jain, Harshita
Dhingra, Dinesh |
| Keywords: | Anxiety
Immobilization
Nitric oxide synthase |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | Effects of selective nitric oxide synthase (NOS)
inhibitors, 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric
oxide synthase (nNOS) and aminoguanidine (AG), a selective inhibitor of
inducible nitric oxide synthase (iNOS) on anxiety in unstressed and stressed
mice were investigated using elevated plus maze (EPM) test and light-dark test
(LDT). 7-NI
(20 and 40 mg/kg, ip) produced anti-anxiety effect in unstressed mice but not
in stressed mice. AG (50 and 100 mg/kg, ip) produced anxiolytic effect in
stressed mice and failed to produce the similar effect in unstressed mice.
Nitrite levels were increased in stressed mice, but not in unstressed mice,
exposed to EPM and LDT for 5 min. Increased nitrite levels in stressed mice were
attenuated by AG, but not by 7-NI. The effects of AG were enhanced by pyrrolidine-dithio-carbamate
(PDTC), an inhibitor of NF-κB induction, in stressed mice. The results suggest
the possible role of inducible nitric oxide synthase in stress-induced anxiogenesis
as compared to unstressed mice, where neuronal form of NOS may plays
pre-dominant role. |
| Page(s): | 365-372 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(04) [April 2010]
|
|
