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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(04) [April 2010] >
| Title: | Microbial transformation of albendazole |
| Authors: | Prasad, G Shyam
Girisham, S
Reddy, S M |
| Keywords: | Albendazole
Albendazole sulfone
Albendazole sulfoxide
Biotransformation |
| Issue Date: | Apr-2010 |
| Publisher: | CSIR |
| Abstract: | Screening scale studies were performed to
biotransform anthelmintic drug albendazole by using twelve bacterial strains
representing six genera and five actinomycetes cultures. Among the cultures
studied, Bacillus subtilis MTCC 619, Escherichia coli MTCC 118 and Klebsiella
pneumoniae MTCC 109 could transform albendazole to one metabolite whereas, Enterobacter aerogenes NCIM 2695, Klebsiella aerogenes NCIM 2258, Pseudomonas aeruginosa NCIM 2074 and
Streptomyces griseus NCIM 2622 could transform albendazole into two
metabolites in significant quantities. The transformation of albendazole was
identified by HPLC. Based on LC-MS-MS data, the two metabolites were predicted
to be albendazole sulfoxide (M1) and albendazole sulfone (M2), the major
mammalian metabolites reported previously. Since M1 is active metabolite, the
results prove the versatility of microorganisms to perform industrially
attractive chemical reactions. |
| Page(s): | 415-420 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(04) [April 2010]
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