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Title: Spectrophotometric determination of frusemide by its oxidation with ceric ammonium sulphate
Authors: Narayana, B
Ashwini, K
Keywords: Frusemide determination;Oxidation;Ceric ammonium sulphate;Spectrophotometry
Issue Date: Mar-2010
Publisher: CSIR
Abstract: A simple and sensitive spectrophotometric method is described for the determination of frusemide (FRU). The method is based on the reaction of FRU with measured excess of ceric ammonium sulphate (CAS) followed by the determination of unreacted oxidant using xylene cyanol FF (XC) (Method A) and safranin O (SAF) (Method B). The reaction mixture exhibited maximum absorbance at 612 nm (Method A) and 526 nm (Method B). The calibration graph was linear from 20.00 to 30.00 µg mL-1 and 6.00 to 16.00 µg mL-1 for methods A and B respectively. The apparent molar absorptivity and Sandell’s sensitivity for method A and B were calculated to be 1.160×104 L mol-1cm-1, 2.025104 L mol-1 cm-1 and 2.82×10-3 µg cm-2, 0.0163 µg cm-2 respectively. The method has been applied for the determination of frusemide in pure and dosage forms.
Page(s): 150-153
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.17(2) [March 2010]

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