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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.17 [2010] >
IJCT Vol.17(2) [March 2010] >
| Title: | Spectrophotometric determination of frusemide by its oxidation with ceric ammonium sulphate |
| Authors: | Narayana, B
Ashwini, K |
| Keywords: | Frusemide determination
Oxidation
Ceric ammonium sulphate
Spectrophotometry |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | A simple and sensitive spectrophotometric
method is described for the determination of frusemide (FRU). The method is
based on the reaction of FRU with measured excess of ceric ammonium sulphate
(CAS) followed by the determination of unreacted oxidant using xylene cyanol FF
(XC) (Method A) and safranin O (SAF) (Method B). The reaction mixture exhibited
maximum absorbance at 612 nm (Method A) and 526 nm (Method B). The calibration
graph was linear from 20.00 to 30.00 µg mL-1 and 6.00 to 16.00 µg mL-1
for methods A and B respectively. The apparent molar absorptivity and
Sandell’s sensitivity for method A and B were calculated to be 1.160×104
L mol-1cm-1, 2.025 104 L mol-1 cm-1 and
2.82×10-3 µg cm-2, 0.0163 µg cm-2
respectively. The method has been applied for the determination of frusemide in
pure and dosage forms. |
| Page(s): | 150-153 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.17(2) [March 2010]
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