|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.67 [2008] >
JSIR Vol.67(02) [February 2008] >
| Title: | Effect of casting solvent on permeability of antihypertensive drugs through ethyl cellulose films |
| Authors: | Murthy, T E Gopala Krishna
Kishore, V Sai |
| Keywords: | Diffusion
Permeability coefficient
Polymer
Solvents
Transmission
Water vapour |
| Issue Date: | Feb-2008 |
| Publisher: | CSIR |
| Abstract: | Ethyl cellulose films were prepared using acetone-methanol (8:2), chloroform-methanol (8:2), dichloromethane-methanol
(8:2) and ethyl acetate-methanol (8:2) as solvents and dibutyl phthalate (40% w/w) as a plasticizer. Solvent evaporation
technique gave thin uniform films. Water vapour transmission and drug diffusion rate of films followed zero order kinetics.
Drug release was governed by peppas model. Diffusion exponent of release profiles (slope) has a value of n>1, which indicates
non analmous transport diffusion. Solvents showed significant influence on water vapour transmission, drug diffusion and
permeability of films. Ethyl acetate:methanol (8:2) showed highest permeability when compared to other films. |
| Page(s): | 147-150 |
| ISSN: | 0022-4456 |
| Source: | JSIR Vol.67(02) [February 2008]
|
|
