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IJC-B Vol.49B(03) [March 2010] >


Title: Improved synthesis of chalcones and pyrazolines under ultrasonic irradiation
Authors: Gupta, Ragini
Gupta, Neetu
Jain, Anshu
Keywords: Chalcones
2-pyrazolines
Claisen-Schmidt condensation
sonochemistry
antimicrobial
Issue Date: Mar-2010
Publisher: CSIR
Abstract:  Five 1,3-diarylprop-2-en-1-ones 3a-e are synthesized by Claisen-Schmidt condensation of aryl methyl ketones and 4-chlorobenzaldehyde to give pyrazolines 5a-e by cyclization with phenylhydrazine in gl. acetic acid using ultrasonic irradiation in lesser time with higher yields. All the synthesized compounds are characterized by elemental analyses and spectral data IR, PMR and are screened for their antimicrobial activities. Some of them have shown promising results against E. coli, S. aureus, C. albicans and A. niger.
Page(s): 351-355
Source:IJC-B Vol.49B(03) [March 2010]

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