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Title: Improved synthesis of chalcones and pyrazolines under ultrasonic irradiation
Authors: Gupta, Ragini
Gupta, Neetu
Jain, Anshu
Keywords: Chalcones;2-pyrazolines;Claisen-Schmidt condensation;sonochemistry;antimicrobial
Issue Date: Mar-2010
Publisher: CSIR
Abstract:  Five 1,3-diarylprop-2-en-1-ones 3a-e are synthesized by Claisen-Schmidt condensation of aryl methyl ketones and 4-chlorobenzaldehyde to give pyrazolines 5a-e by cyclization with phenylhydrazine in gl. acetic acid using ultrasonic irradiation in lesser time with higher yields. All the synthesized compounds are characterized by elemental analyses and spectral data IR, PMR and are screened for their antimicrobial activities. Some of them have shown promising results against E. coli, S. aureus, C. albicans and A. niger.
Page(s): 351-355
Appears in Collections:IJC-B Vol.49B(03) [March 2010]

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