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IJC-B Vol.49B [2010] >
IJC-B Vol.49B(03) [March 2010] >

Title: Synthesis of bis(arylamino)thiazoloylindoles as novel analogs of dendrodoine
Authors: Reji, T F Abbs Fen
Manju, S L
Rajasekharan, K N
Keywords: Analogs
Issue Date: Mar-2010
Publisher: CSIR
Abstract: 3-[2,4-Bis(arylamino)thiazol-5-oyl]indoles, as the analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized from 1-(N,N'-diarylamidino)-3-arylthioureas which provided the four [S1-C2-N3-C4] ring atoms for the thiazole ring construction. The remaining carbon of the thiazole is sourced from 3-(2-bromoacetyl)indole. This [4+1] heterocyclization reaction provided novel 3-[2,4-bis(arylamino)thiazol-5-oyl]indoles, which are characterized by elemental analysis, IR, NMR and FAB Mass spectral data and showed moderate antibacterial activity.
Page(s): 323-326
Source:IJC-B Vol.49B(03) [March 2010]

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