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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(03) [March 2010] >
| Title: | Synthesis of bis(arylamino)thiazoloylindoles as novel analogs of dendrodoine |
| Authors: | Reji, T F Abbs Fen
Manju, S L
Rajasekharan, K N |
| Keywords: | Analogs
dendrodoine
cytotoxic
arylamino
thiazole
indole |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | 3-[2,4-Bis(arylamino)thiazol-5-oyl]indoles, as the analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized
from 1-(N,N'-diarylamidino)-3-arylthioureas which provided the
four [S1-C2-N3-C4] ring atoms for the thiazole ring construction. The remaining carbon
of the thiazole is sourced from 3-(2-bromoacetyl)indole. This [4+1]
heterocyclization reaction provided novel 3-[2,4-bis(arylamino)thiazol-5-oyl]indoles,
which are characterized by elemental analysis, IR, NMR
and FAB Mass spectral data and showed moderate antibacterial activity. |
| Page(s): | 323-326 |
| Source: | IJC-B Vol.49B(03) [March 2010]
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