Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/7536
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dc.contributor.authorThadhaney, Bhawana-
dc.contributor.authorSain, Devendra-
dc.contributor.authorPemawat, Gangotri-
dc.contributor.authorTalesara, G L-
dc.date.accessioned2010-03-08T05:09:17Z-
dc.date.available2010-03-08T05:09:17Z-
dc.date.issued2010-03-
dc.identifier.urihttp://hdl.handle.net/123456789/7536-
dc.description368-373en_US
dc.description.abstractThe synthesis of 3′-{(4-substituted phenyl-1-N-ethoxy­phthali­mido-6′-pyridin-2-yl}-3,3a′-dihydro-6′H-spiro[indole-3,5′-[1,3]­thi­a­zolo­[4,5-c]­isoxazol]-2(1H)-ones 6a-d is carried out  through a five step pathway starting from acid catalyzed condensation of 2-aminopyridine with isatin yielding 3-(pyridin-2-ylimino)-1,3-dihydro-2H-indol-2-one 1 which on reaction with thioacetic acid in the presence of anhydrous ZnCl2 give 3′-pyridin-2-yl-4′H-spiro[indole-3,2′-[1,3]­thiazolidine]-2,4′(1H)-dione 2. Reaction of 2 with various aralde­hydes 3a-d affords the corresponding 5′-[(4-substituted phenyl)­methylidene]-3′-pyridin-2-yl-4′H-spiro­[indole-3,2′-[1,3]­thiazoli­dine]-2,4′(1H)-diones 4a-d. These chal­cones are further cyclised with hydroxylamine hydrochloride to furnish 3′-(4-substituted phenyl)-6′-pyridin-2-yl-3,3a′-dihydro-6′H-spiro[indole-3,5′-[1,3]thia­zolo[4,5-c]isoxazol]-2(1H)-ones 5a-d which are subsequently condensed with ω-bromo­ethoxy­phthalimide to yield the targeted compounds 6a-d. Structural confirmation of the synthesized compounds has been accomplished by IR, 1H NMR, and mass spectral data. Final compounds have been screened for their antimicrobial activity.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJC-B Vol.49B(03) [March 2010]en_US
dc.subjectIsatinen_US
dc.subject2-aminopyridineen_US
dc.subjectthiazolidinoneen_US
dc.subjectisoxazoleen_US
dc.subjectω-bromoethoxyphthalimideen_US
dc.titleSynthesis and antimicrobial evaluation of ethoxyphthalimide derivatized spiro [indole-3,5′-(1,3)thiazolo(4,5-c)isoxazol]-2(1H)-ones via ring closure metathesisen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.49B(03) [March 2010]

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