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http://nopr.niscair.res.in/handle/123456789/7530| Title: | Synthesis and anti-inflammatory activity of fluorinated propanedione derivatives |
| Authors: | More, Arpita H Ramaa, C S |
| Keywords: | Difluorinated propanediones;dibromostyryl ketones;chalcones;anti-inflammatory activity;acute toxicity studies |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | A new series of five 1-(2′,4′-difluorophenyl)-3-(substituted phenyl)-1,3 propanediones from 2′,4′-difluorinated chalcones have been synthesized. All the compounds (20 mg/kg po) possess anti-inflammatory activity, as reflected by their ability to provide protection (70.00 - 93.00%) against carrageenan induced edema in rat paw. Standard indomethacin provided 79.00% protection at the same dose. The safety of these substituted propanediones are reflected by toxicity studies. |
| Page(s): | 364-367 |
| URI: | http://hdl.handle.net/123456789/7530 |
| Appears in Collections: | IJC-B Vol.49B(03) [March 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 49B(3) 364-367.pdf | 151.57 kB | Adobe PDF | View/Open |
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