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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(03) [March 2010] >
| Title: | Synthesis and anti-inflammatory activity of fluorinated propanedione derivatives |
| Authors: | More, Arpita H
Ramaa, C S |
| Keywords: | Difluorinated propanediones
dibromostyryl ketones
chalcones
anti-inflammatory activity
acute toxicity studies |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | A new series of five 1-(2′,4′-difluorophenyl)-3-(substituted
phenyl)-1,3 propanediones from 2′,4′-difluorinated chalcones have been
synthesized. All the compounds (20 mg/kg po) possess anti-inflammatory
activity, as reflected by their ability to provide protection (70.00 - 93.00%) against carrageenan induced edema in rat paw. Standard indomethacin
provided 79.00% protection at the same dose. The safety of
these substituted propanediones are reflected by toxicity studies. |
| Page(s): | 364-367 |
| Source: | IJC-B Vol.49B(03) [March 2010]
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