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Title: Synthesis and anti-inflammatory activity of fluorinated propanedione derivatives
Authors: More, Arpita H
Ramaa, C S
Keywords: Difluorinated propanediones;dibromostyryl ketones;chalcones;anti-inflammatory activity;acute toxicity studies
Issue Date: Mar-2010
Publisher: CSIR
Abstract: A new series of five 1-(2′,4′-difluorophenyl)-3-(substituted phenyl)-1,3 propanediones from 2′,4′-difluorinated chalcones have been synthesized. All the compounds (20 mg/kg po) possess anti-inflammatory activity, as reflected by their ability to provide protection (70.00 - 93.00%) against carrageenan induced edema in rat paw. Standard indomethacin provided 79.00% protection at the same dose. The safety of these substituted propanediones are reflected by toxicity studies.
Page(s): 364-367
Appears in Collections:IJC-B Vol.49B(03) [March 2010]

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