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dc.contributor.authorVinod, N V-
dc.contributor.authorHaridas, M-
dc.contributor.authorSadasivan, C-
dc.identifier.issn0975-0959 (Online); 0301-1208 (Print)-
dc.description.abstractAntimicrobials derived from plants have been receiving increasing attention in recent years. Antimicrobial activities of a number of phytochemicals have been reported. Many present day antibiotics are ineffective against several pathogenic organisms. About 90% of Staphylococcus aureus isolates from clinical specimens is reported to have resistance against β-lactam antibiotics. In the present study, the effect of hexane, diethyl ether, acetone and water extracts of leaves of a medicinal plant Holoptelea integrifolia has been tested against β-lactam resistant strain of S. aureus in presence of antibiotics such as ampicillin, amoxicillin, cefotaxime and ceftriaxone. The diethyl ether extract has shown the maximum antibacterial activity and the active principle is found to be 1,4-naphthalenedione which is characterized by GC-MS and FTIR spectroscopy. The minimum inhibitory concentration (MIC) of the compound is found to be 4 mg/ml. Structural similarity of this compound with a func- tional group of a β-lactamase-resistant antibiotic indicates that 1,4-naphthlenedione may be acting as an inhibitor to β-lactamase.en_US
dc.sourceIJBB Vol.47(1) [February 2010]en_US
dc.subjectStaphylococcus aureusen_US
dc.subjectAntibacterial activityen_US
dc.subjectHoloptelea integrifoliaen_US
dc.subjectβ-Lactam antibioticsen_US
dc.titleIsolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holoptelea integrifolia and its activity against β-lactam resistant Staphylococcus aureus en_US
Appears in Collections:IJBB Vol.47(1) [February 2010]

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