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Title: Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of<i style=""> Holoptelea integrifolia </i>and its activity against β-lactam resistant <i style="">Staphylococcus aureus </i>
Authors: Vinod, N V
Haridas, M
Sadasivan, C
Keywords: <i style="">Staphylococcus aureus</i>
Antibacterial activity
<i style="">Holoptelea integrifolia</i>
β-Lactam antibiotics
Issue Date: Feb-2010
Publisher: CSIR
Abstract: Antimicrobials derived from plants have been receiving increasing attention in recent years. Antimicrobial activities of a number of phytochemicals have been reported. Many present day antibiotics are ineffective against several pathogenic organisms. About 90% of <i style="">Staphylococcus aureus</i> isolates from clinical specimens is reported to have resistance against β-lactam antibiotics. In the present study, the effect of hexane, diethyl ether, acetone and water extracts of leaves of a medicinal plant <i style="">Holoptelea integrifolia </i>has been tested against β-lactam resistant strain of <i style="">S. aureus </i>in presence of antibiotics such as ampicillin, amoxicillin, cefotaxime and ceftriaxone. The diethyl ether extract has shown the maximum antibacterial activity and the active principle is found to be 1,4-naphthalenedione which is characterized by GC-MS and FTIR spectroscopy. The minimum inhibitory concentration (MIC) of the compound is found to be 4 mg/ml. Structural similarity of this compound with a func- tional group of a β-lactamase-resistant antibiotic indicates that 1,4-naphthlenedione may be acting as an inhibitor to β-lactamase.
Description: 53-55
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.47(1) [February 2010]

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