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Title: Amelioration of alcohol-induced oxidative stress by Emblica officinalis (Amla) in rats
Authors: Reddy, V Damodara
Padmavathi, P
Paramahamsa, M
Varadacharyulu, N C
Keywords: Alcohol
Emblica officinalis
Lipid profile
Nitric oxide
Oxidative stress
Issue Date: Feb-2010
Publisher: CSIR
Abstract: The present study was aimed at investigating the ameliorative effect of Emblica (Phyllanthus Emblica. L) fruit extract (EFE) against alcohol-induced oxidative changes in plasma biochemical profile in rats. Alcohol administration (5 g/kg body wt/day) for 60 days resulted in significantly (P<0.05) higher levels of plasma nitrite/nitrate (NOx), total bilirubin, creatinine, and abnormalities in lipid and lipoproteins. Moreover, alcohol receiving rats showed significantly (P<0.05) lowered plasma total protein, albumin/globulin (A/G) ratio and uric acid, with no significant change in glucose level. The EFE administration (250 mg/kg body wt/day) to alcohol-administered rats significantly modulated plasma lipids and lipoprotein patterns and also decreased nitrite/nitrate, total bilirubin and creatinine levels. EFE administration to alcohol receiving rats showed a significant (P<0.05) increase in plasma total protein, A/G ratio and uric acid levels. Total cholesterol (r = 0.466), triglycerides (r = 0.574), VLDL-C (r = 0.578), LDL-C (r = 0.225) and total bilirubin (r = 0.419) showed a stronger positive correlation with that of NOx in alcohol-treated rats. The concentration of nitric oxide (NOx) was negatively correlated with HDL-C (r = -0.285) and uric acid (r = 0.392) in alcohol-treated rats. The amelioration of alcohol-induced oxidative stress might be due to the combined effect of phytophenols, such as tannins and flavonoid compounds and vitamin C.
Page(s): 20-25
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.47(1) [February 2010]

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